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Bioavailability following subcutaneous injection is estimated at approximately 80%, substantially higher than oral administration, where peptide degradation in the gastrointestinal tract limits systemic exposure

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The role of GLP-1R in type 2 diabetes mellitus (T2DM) is highlighted, emphasizing its pivotal contribution to glucose homeostasis, promoting -cell proliferation, and facilitating insulin release

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Ongoing research to establish predictive biomarkers for the treatment of tumours with resistance to SG-ARAs led to the approval of the PARP inhibitors olaparib and rucaparib in pre-treated metastatic castration-resistant prostate cancer

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